慢性周围假肢关节感染患者的比例与Candida分离
Samuelson E Osifo1, Adrian Santana1, Michael F Shannon2
1Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Journal of bone and joint infection
|January 23, 2026
概括
真菌周围假肢关节感染 (PJI) 可能是报告不足的. 这项研究估计,与Candida相关的PJI的发病率约为5%,在慢性,耐火病例中高达10%.
科学领域:
- 传染性疾病 传染性疾病
- 医学真菌学 医学真菌学
- 整形外科手术 整形外科手术
背景情况:
- 由于诊断局限性,真菌周围假肢关节感染 (PJI) 经常被低估.
- 在PJI中,Candida物种是最常见的真菌病原体.
- 目前的诊断方法对于检测真菌参与的敏感性很低.
研究的目的:
- 量化PJI中未被认可的真菌参与的负担.
- 为了提供一个更准确的发生率估计的Candida相关的PJI.
- 为了调整报告的真菌PJI病例中不足的确定性.
主要方法:
- 系统的文献搜索和定量敏感性分析.
- 以信息性缺失概率比率 (IMORs) 进行推算,以调整不足的确定.
- 针对单个阳性,阴性和多微生物培养的调整,以及真菌培养敏感度的变化.
主要成果:
- 对23项涉及28253名PJI患者的研究进行了分析;2.1%的人报告了Candida的参与.
- 调整后的Candida相关PJI发病率估计在1.4%-13.6%之间,平均值为5.1%.
- 慢性耐火性PJI病例的估计发病率超过10%.
结论:
- 在PJI中,Candida的参与被严重低估.
- 与坎迪达菌相关的PJI的总体发病率约为5%.
- 在慢性耐火性PJI中,特别是在多次手术后,Candida PJI发病率接近10%.
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