老年败血症患者的预后营养指数和28天死亡率:基于MIMIC数据库的回顾性分析
Yuewen Yang1, Zhihong Zhou1, Huajie Dai2
1Department of Intensive Care, Shunde Hospital, Guangzhou University of Chinese Medicine, Foshan, China.
Northern clinics of Istanbul
|January 23, 2026
概括
极端预后营养指数 (PNI) 值与老年败血症患者28天死亡率较高有关. 这项研究揭示了非线性关系,表明PNI可以帮助预测败血症的结果.
科学领域:
- 老年医学 老年医学
- 关键护理医学 关键护理医学
- 营养科学 营养科学
背景情况:
- 周围血液淋巴细胞计数和血清白蛋白是已知的败血症死亡率预测因素.
- 以前的研究集中在单个指标上,忽视了它们的综合预后价值.
- 预后营养指数 (PNI) 整合了白蛋白和淋巴细胞,以进行全面的营养评估.
研究的目的:
- 调查预后营养指数 (PNI) 与老年败血症患者28天全因死亡率之间的关联.
- 探索PNI和死亡风险之间的非线性关系.
- 评估PNI在败血症预后风险分层中的实用性.
主要方法:
- 从MIMIC-IV数据库 (2008-2019) 中对2,121名老年败血症患者进行了回顾性分析.
- 根据28天的结果将其分为生存和死亡组.
- 限制立方线 (RCS) 分析,卡普兰-梅尔曲线和考克斯回归模型,以评估PNI对死亡率的影响.
主要成果:
- 与生存组相比,非生存组的PNI值明显较低.
- 在PNI和28天死亡风险之间观察到非线性关系.
- 极端PNI值 (低或高) 独立地与28天全因死亡率的增加有关 (HR=1.349,p=0.004).
结论:
- 这项研究表明,老年败血症患者的PNI和28天死亡率之间存在非线性关联.
- 极端PNI值被确定为死亡率的独立风险因素.
- 普尼显示承诺作为一个有效的工具预后风险分层在败血症.
相关概念视频
The Roles of Bacteria and Fungi in Plant Nutrition
47.2K
Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
47.2K
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
836
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
836
Microbial Nutrition
1.1K
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
1.1K
Key Elements for Plant Nutrition
24.1K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.1K
Enteral Nutrition I: Orogastric and Nasogastric Feeding
1.3K
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
1.3K
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
905
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
905


