微针透阵列与轴尺寸尺寸为无袖外围神经接口
Dongxiao Yan1, Ahmad Jiman2, David Ratze1
1University of Michigan Department of Electrical Engineering & Computer Science, Ann Arbor, MI, 48109 USA.
概括
研究人员开发了一种新的,超小型化的微针阵列,用于绘制小自主神经的地图. 这种没有袖子的装置提供了精确的控制和神经接口的独特手术技术.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 材料科学 材料科学 材料科学
背景情况:
- 自主神经对于交感和副交感控制至关重要,在器官目标附近的直径通常只有数百微米.
- 现有的与小神经接口的方法通常涉及重的手,限制精度,并可能造成损伤.
研究的目的:
- 设计和制造一个超小型的,没有袖口的微针阵列,用于绘制小自主神经的地图.
- 开发一种新的外科手术技术,用于安全,无袖的微针阵列植入.
主要方法:
- 在基板上制造高密度微针阵列 (25-100针),具有1微米尖端和双收缩轴.
- 控制针尖和轴角,以获得最佳的度和刚度.
- 开发一种使用光化学粘合的手术技术,将原蛋白/孟加拉粘合剂粘合到epineurium上,用于无袖阵列固定.
主要成果:
- 展示了具有可控制针形状的阵列,以及在弹性基板上稳定的后侧.
- 成功制造出能够围绕300微米神经包裹的阵列.
- 提出了一种可行的手术方法,可以在没有袖口的情况下植入0.3mm x 1.2mm小的阵列.
结论:
- 开发的超小型化微针阵列和手术技术对精确地绘制小自主神经的准确绘制有希望.
- 这种无袖子的方法比传统的神经接口方法提供了潜在的进步.
- 未来的研究将涉及在老鼠迷走神经模型中的设备功能化和验证.
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