压力对儿童骨健康的影响
Zaineb Sohail1,2, Norhayati Binti Abd Hadi1, Edna Hiu Tung Lam3
1Faculty of Health Sciences, Universiti Sultan Zainal Abidin - UniSZA, Kuala Terengganu, Malaysia.
Frontiers in endocrinology
|January 23, 2026
概括
慢性心理压力通过影响生长和发育,对儿科骨健康产生负面影响. 研究强调需要对儿童的压力,氧化压力和骨积累进行研究.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨生物学 骨生物学
- 心理神经免疫学 心理神经免疫学
背景情况:
- 慢性心理压力是一个重要的公共卫生问题,与各种疾病有关,包括骨健康受损.
- 虽然已知成人压力与骨健康的联系,但儿科数据有限,需要对儿童骨积累进行研究.
- 压力通过内分泌,免疫,饮食,体力活动,药物和睡眠途径影响骨.
研究的目的:
- 审查关于心理压力对儿科骨健康的影响的临床和临床前证据.
- 阐明将压力与儿童骨失调联系在一起的机制.
- 识别儿童压力和骨健康方面的知识差距和未来研究方向.
主要方法:
- 临床前 (动物) 和临床 (人类) 研究的综述.
- 分析包括内分泌,免疫和氧化应激途径在内的机制.
- 检查诸如饮食,体育活动,睡眠和药物等因素.
主要成果:
- 压力通过多种途径影响儿科骨健康,包括内分泌和免疫系统.
- 增加的压力会增加氧化压力,损害干细胞分化和骨形成.
- 促炎性细胞因子 (TNF-α,IL-6) 和葡萄糖皮质类药物加剧细胞氧化应激.
结论:
- 心理压力对儿科骨健康和发育构成重大风险.
- 氧化压力及其下游影响是压力诱导的骨缺陷的关键调解因素.
- 针对氧化应激的干预措施可能为减轻骨损伤提供治疗潜力.
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