在多发性硬化症中,白色和灰色物质的T1和分散张量为基础的碎形维度
Weronika Mazur-Rosmus1, Zofia Schneider1, Agnieszka Słowik2
1LaTiS NMR Tomography and Spectroscopy Laboratory, Department of Fossil Fuels, Faculty of Geology, Geophysics and Environmental Protection, AGH University of Krakow, Krakow, Poland.
Frontiers in neurology
|January 23, 2026
概括
分形维度 (FD) 结合扩散张力成像 (DTI) 度量,如分数异构 (FA) 和平均扩散度 (MD),显著提高了多发性硬化症 (MS) 脑部变化的诊断. 这种几何微观结构的整合为检测早期疾病变化的准确性提供了改进.
科学领域:
- 神经成像是一种神经成像.
- 生物医学工程 生物医学工程
- 放射学 放射学是一门学科.
背景情况:
- 多发性硬化症 (MS) 导致正常出现的白质 (NAWM) 和灰质 (GM) 的早期大脑微观结构变化.
- 扩散张力成像 (DTI) 检测到微观结构的改变,而碎形维度 (FD) 量化组织的复杂性.
- 现有的DTI指标,如分数异构性 (FA) 和平均扩散性 (MD),评估组织完整性.
研究的目的:
- 调查基于T1的FD是否在MS中提供了超出DTI指标的额外诊断价值.
- 评估将FD与FA和MD结合用于MS检测的诊断性能.
主要方法:
- 分析了120名复发性复发性MS患者和75名健康对照者的MRI数据.
- 在全球大脑组织和白质 (WM) 骨中量化FD,FA和MD,带有和没有病变掩饰.
- 构建分类模型来评估综合指标的诊断性能.
主要成果:
- 多发性硬化症白质量显示FD和FA减少,MD升高,表明脱髓化和轴突损伤.
- 灰色物质表现出更高的FD,FA和MD,表明复杂的重塑和适应.
- 将FD与FA和MD结合起来,大大提高了分类准确性,特别是在WM骨架分析中.
结论:
- 基于T1的FD为MS的DTI指标提供了补充的诊断信息.
- FD,FA和MD的几何微结构整合显示出MS的显著诊断潜力.
- 通过这些指标检测到的分散白质变化与临床衰退相关.
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