在内动脉瘤破裂或生长时 (ChATIA-1试验) 进行增强与标准血压降低:为多中心,前性,开放式随机对照试验的协议
Kaige Zheng1,2, Shaohua Mo3, Zheng Wen1,2
1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Frontiers in neurology
|January 23, 2026
概括
这项研究调查了未破裂的内动脉瘤 (UIAs) 患者的最佳血压目标. 将标准降血压与强化降血压进行比较,旨在降低动脉瘤不稳定性和破裂风险.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 临床试验 临床试验
背景情况:
- 高血压是患有未破裂内动脉瘤 (UIAs) 的患者常见的并发症.
- 血压升高与动脉瘤的不稳定性有关.
- 管理UIA的最佳血压目标尚未明确.
研究的目的:
- 确定最佳的血压范围,以减少UIA患者的不稳定性.
- 为了比较标准降血压 (SBPL) 与增强降血压 (EBPL) 在治疗UIA的疗效.
主要方法:
- 一个多中心,前性,开放标签,随机对照试验,涉及570名患有UIA和高血压的患者.
- 患者被随机分配到SBPL (静态血压120-140 mmHg) 或EBPL (静态血压<120 mmHg).
- 主要结局:动脉瘤的不稳定性 (生长或破裂) 在24个月内进行评估. 每月监测血压;在6个月,12个月和24个月进行放射学检查.
主要成果:
- 该试验的功率为检测动脉瘤不稳定性的60%降低,功率为85%.
- 结果将提供关于不同血压目标有效性的证据.
结论:
- 中国对内动脉瘤的抗高血压试验 (ChATIA) 将为UIA患者的血压管理提供新的证据.
- 预计这些发现将为管理内动脉瘤患者高血压的临床指南提供信息.
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