单细胞IL-1β预测不良心血管事件,并与冠状动脉微血管功能障碍相关,在移植接受者
Zhengwei Yin1, Qingyan Yang1, Jianle Han1
1Kidney Transplantation and Nephrology Treatment Center, The Seventh People's Hospital of Zhengzhou, Zhengzhou, China.
Frontiers in cardiovascular medicine
|January 23, 2026
概括
在移植前,单细胞中介质素-1β (IL-1β) 基因表达预测了移植接受者 (KTRs) 的死亡率和主要不良心血管事件 (MACE). 较高的IL-1β水平与冠状动脉微血管功能障碍 (CMD) 有关.
科学领域:
- 移植免疫学 移植免疫学
- 心血管研究研究心血管研究
- 分子生物学分子生物学
背景情况:
- 心血管疾病是移植后死亡的主要原因.
- 冠状动脉微血管功能障碍 (CMD) 在移植接受者 (KTRs) 中普遍存在,并与炎症有关.
- 与热症相关的基因与心血管健康相关的炎症过程有关.
研究的目的:
- 为了调查是否与热致死相关基因 (IL-1β,GSDMD,Caspase-1,NLRP3) 的移植前单细胞表达预测了KTRs的长期死亡率和MACE.
- 评估这些基因表达与KTRs中的CMD之间的关联.
主要方法:
- 注册了305个KTR,在手术前分离了单细胞.
- 定量PCR (qPCR) 测量了IL-1β,GSDMD,Caspase-1和NLRP3.3的表达.
- 多变量考克斯回归分析了死亡率和MACE预测,而CMD则通过冠状动脉流量储备 (CFR) 和血清综-1水平进行评估.
主要成果:
- 在平均4.0年的时间里,20.3%的KTR经历了MACE.
- 升高的IL-1β表达独立预测死亡 (aHR 1.530) 和MACE (aHR 1.622).
- 较高的IL-1β与CFR (R=-0.40) 反向相关,与syndecan-1 (R=0.47) 相对相关,表明与CMD有联系.
结论:
- 单细胞IL-1β表达是KTRs中死亡率和MACE的重要独立预测因子.
- 这些发现表明IL-1β,CMD和KTRs中的不良心血管结果之间存在机械联系.
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