相关实验视频
Updated: Jan 24, 2026

11:29
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
11.2K
阐明SHROOM4在非小细胞肺癌中的作用:表达模式,临床相关性和潜在功能
Yuqi Zhang1, Rong Qiang1, Mengyang Ding2
1Center of Medical Genetics, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, China.
Frontiers in immunology
|January 23, 2026
概括
在非小细胞肺癌 (NSCLC),特别是肺状细胞癌 (LUSC) 中,SHROOM4蛋白被下调. 它的表达与较差的结果相关,并影响瘤微环境,表明作为诊断和治疗点的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 肺癌是全球癌症死亡的主要原因,非小细胞肺癌 (NSCLC) 是最常见的亚型.
- 在NSCLC的背景下,参与细胞骨组织和信号的蛋白质SHROOM4尚未被彻底研究.
研究的目的:
- 用生物信息学分析研究NSCLC中SHROOM4的表达.
- 探索SHROOM4表达,临床结果和肺癌潜在机制之间的关系.
- 在肺状细胞癌 (LUSC) 组织中验证SHROOM4mRNA和蛋白质水平.
主要方法:
- 公共数据库的生物信息分析,以评估SHROOM4表达和临床相关性.
- 在LUSC组织与正常组织中验证SHROOM4mRNA和蛋白质表达.
- 单细胞RNA测序和差异表达分析以确定细胞局部化和相关途径.
主要成果:
- 在肺癌,特别是LUSC中,SHROOM4表达显著下调,显示出高诊断能力.
- 较高的SHROOM4水平与较差的临床结果相关,包括降低生存率和晚期疾病.
- 树突细胞中的SHROOM4表达与血管生成和Wnt/Beta-Catenin通路有关,与PTPN13/CACNA1C共同表达,并且与NSCLC中的免疫透具有积极的相关性.
结论:
- SHROOM4具有作为诊断和治疗的抗癌点的潜力,特别是在LUSC.
- 通过调节瘤微环境,SHROOM4可能会影响NSCLC的进展.
- 需要进一步的研究,以充分阐明SHROOM4在肺癌中的作用和临床实用性.
相关概念视频
Cell Potential and Free Energy
46.3K
Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.3K
Correlations
35.8K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.8K
Correlation and Causation
42.3K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.3K
Cell Specific Gene Expression
16.3K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.3K
Lung Capacity
56.2K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.2K
Chromatin Position Affects Gene Expression
24.7K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.7K

