与HPV 16同时感染对宫病理的影响比单独感染HPV 16更糟吗?
Aysun Alci1, Necim Yalcin2, Mustafa Gokkaya3
1Department of Gynecologic Oncology, Kahramanmaras Necip Fazil City Hospital, Kahramanmaras, Türkiye.
概括
人类乳头瘤病毒 (HPV) 16型是高度宫问题的主要驱动因素. 与其他HPV基因型的同时感染不会使病理结果恶化,但可能会增加异常的结肠镜检查结果.
科学领域:
- 妇科瘤学 妇科瘤学
- 病毒学 病毒学
- 病理学 病理学 病理学
背景情况:
- 宫癌查依赖于人类乳头瘤病毒 (HPV) 检测.
- HPV16是一种高风险的基因型,与子宫病理密切相关.
- 与HPV16一起与其他HPV基因型的同时感染对宫病理结果的影响需要进一步澄清.
研究的目的:
- 确定与HPV16以外的HPV基因型的同时感染是否会对HPV16阳性个体的病理结果产生负面影响.
- 调查HPV16同时感染与组织病理学发现,结肠镜检查结果和风险因素之间的关联.
主要方法:
- 对2700名来自妇科瘤诊所的HPV阳性女性 (2017-2025) 的回顾性分析.
- 纳入标准:HPV16阳性患者,有或没有其他HPV基因型.
- 使用混合捕获2和CLART基因组学系统进行的HPV基因型鉴定.
主要成果:
- 只有HPV16和HPV16同时感染的组之间在高度子宫病理 (CIN 2/3,HSIL,侵入性癌症) 中没有显著差异.
- 在HPV16联合感染组 (p=0.037) 中,异常的结肠镜检查结果更为普遍.
- 吸烟与HPV16联合感染的风险增加1.27倍 (p=0.026).
结论:
- 无论其他HPV基因型如何,HPV16是高度宫病理的主要决定因素.
- 同时感染不会显著恶化组织病理结果,但与更普遍的异常结肠镜检查结果有关.
- 支持基于风险的宫癌查和HPV16阳性个体的早期干预.
相关概念视频
Cattell's 16 Personality Factors
2.4K
Raymond Cattell's trait theory offers a structured framework for understanding personality by distinguishing between two critical traits: surface and source traits. Surface traits are observable patterns of behavior, such as indecisiveness, anxiety, and irrational fears. These traits are less stable, varying across situations and over time. This means that they are less helpful in understanding the deeper aspects of an individual's personality.
In contrast, source traits are the...
In contrast, source traits are the...
2.4K
Infection
12.0K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
12.0K
Stages of Infection
65.1K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
65.1K
Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
Sexually Transmitted Infections
958
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
958
Defense Mechanism Against Infection
9.3K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
9.3K


