对女孩的比较分析 缓慢进步的中部早熟青春期与早期青春期. 快速进步的中部早期青春期:单一中心的经验
Busra Tetik Dincer1, Aydilek Dagdeviren Cakir2, Ahmet Ucar2
1Department of Pediatrics, Dr. Sami Ulus Children's Health and Diseases Training and Research Hospital, Ankara, Türkiye.
概括
快速进展的早期青春期 (RP-CPP) 可以通过较高的骨年龄与时间学年龄比率来识别. 早期检测和个性化评估是CPP治疗决策的关键.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖健康 生殖健康
- 增长和发展 增长和发展
背景情况:
- 中部早期青春期 (CPP) 呈现为缓慢进展 (SP-CPP) 或快速进展 (RP-CPP).
- 在CPP中,进展速度对于治疗决策至关重要.
- 了解影响RP-CPP进展的因素至关重要.
研究的目的:
- 为了比较治疗和未治疗的CPP患者之间的临床数据.
- 确定影响RP-CPP进展的因素.
- 评估骨年龄/年代年龄比在确定RP-CPP时的有用性.
主要方法:
- 单中心回顾性观察性研究.
- 406名5-8岁的女性患者患有CPP.
- 分类为SP-CPP (n=252,没有GnRHa) 和RP-CPP (n=154,有GnRHa) 组.
- 对临床,实验室和放射学发现的分析.
主要成果:
- 在SP-CPP和RP-CPP组之间,发病时的中位数年龄没有显著差异.
- 在RP-CPP组中显著更高的坦纳乳房阶段,LH,FSH,雌激素,LH峰值,骨龄/年代年龄比.
- 多变量分析确定了坦纳乳房阶段和骨年龄/年代年龄比率作为RP-CPP的重要参数.
结论:
- 骨年龄/年代年龄比率是RP-CPP早期检测的一个重要参数.
- 对临床,实验室和放射学发现的集体评估对于CPP的分类至关重要.
- 对CPP的治疗决定应基于个别评估.
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