病例报告:Trastuzumab deruxtecan在人类表皮生长因子受体2-突变的肺癌中与连续脏替代疗法治疗
Sumin Wu1, Chengming Ke2, Min Wei1
1Center of Excellence, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Frontiers in oncology
|January 23, 2026
概括
特拉斯图祖马布德鲁克斯泰干 (T-DXd) 在患有HER2突变非小细胞肺癌 (NSCLC) 的患者中显示出可管理的毒性和疾病控制,需要持续的代疗法 (CRRT). 对这种特定的患者群体需要进行进一步的研究.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- HER2突变非小细胞肺癌 (NSCLC) 是一种罕见的,攻击性的,对标准治疗反应不佳的疾病.
- 特拉斯图苏巴 (T-DXd) 是一种针对HER2的抗体-药物联合体 (ADC),在HER2突变癌症中显示出前景.
- 在需要持续置换疗法 (CRRT) 的功能障碍患者中,T-DXd的安全性和有效性尚未得到充分证实.
研究的目的:
- 评估T-DXd在患有晚期HER2突变NSCLC和需要CRRT的功能障碍的患者中的安全性和有效性.
- 评估T-DXd在这个特定的患者亚组中的临床结果和毒性概况.
主要方法:
- 一个69岁的女性病例报告,患有先进的HER2突变NSCLC和急性损伤 (AKI),需要CRRT.
- 在多学科讨论和标准化疗失败后开始T-DXd治疗.
- 监测不良事件和临床反应,包括成像研究和症状评估.
主要成果:
- 治疗T-DXd导致疾病控制,症状改善 (降低,腹部张张,出血),并在三个周期后疾病稳定.
- 患者经历了严重的骨髓抑制,这在支持性护理下得到缓解.
- 没有观察到明显的间歇性肺病,肝毒性或进一步的毒性.
结论:
- 在患有HER2突变肺癌的CRRT依赖患者中,T-DXd证明了潜在的临床实用性,实现了可控毒性的疾病控制.
- 由于吸收的短生存期需要谨慎的解释和在更大的队列中进一步验证.
- 在HER2突变NSCLC患者中T-DXd在功能障碍患者中的作用需要进一步调查.
更多相关视频
08:28Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
Published on: May 9, 2025
702
09:53Labeling of Breast Cancer Patient-derived Xenografts with Traceable Reporters for Tumor Growth and Metastasis Studies
Published on: November 30, 2016
12.7K
相关概念视频
01:30Continuous Renal Replacement Therapy
934
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
934
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
194
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
194
01:17Factors Affecting Renal Clearance: Renal Impairment
434
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
434
02:49Cancer Therapies
9.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.9K
01:28Role of Hematopoietic Growth Factors
3.2K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
3.2K
01:29Factors Influencing Microbial Growth: pH
1.1K
Microorganisms are classified as acidophiles, neutrophiles, or alkaliphiles based on their pH growth preferences, reflecting their adaptations to specific environments. Maintaining a stable intracellular pH is critical for macromolecular stability and enzymatic activity, which can be challenged by external pH variations.Neutrophiles, such as Escherichia coli, grow optimally between pH 5.5 and 8.0. These microorganisms inhabit neutral or slightly acidic environments and employ mechanisms like...
1.1K