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Updated: Jan 24, 2026

Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain
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关于维里丹斯 (Viridans Streptococci) 结合糖的结构基础是如何容纳超出特征结合位点的连接体

KeAndreya M Morrison1, Kole Martin2, Hai Yu3

  • 1Department of Pharmacology, Meharry Medical College, Nashville, TN, US.

microPublication biology
|January 23, 2026
PubMed
概括

维里达人群链球菌通过使用类似于siglec的蛋白质与宿主血小板结合,这些蛋白质可以识别有酸覆盖的甘氨酸. 这项研究揭示了关键蛋白质-碳水化合物相互作用的晶体结构,解释了更大的甘氨酸连接物是如何结合的.

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Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
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The Equilibrium Binding Constant and Binding Strength

The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
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