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斯皮罗诺拉克,埃普莱伦和菲内伦的比较安全性概况:基于2004年至2024年FAERS数据的药监测研究

Kaiyun Ji¹, Xingjun Huang², Fang Wang³

¹Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Frontiers in pharmacology

|January 23, 2026

概括

矿物质皮质类受体抗剂 (MRAs),如螺旋,eplerenone和finerenone,具有不同的安全性. 费内伦对高血和脏问题显示出更强烈的信号,而螺旋龙则具有更多的荷尔蒙副作用.

科学领域:

药物监督药物监督药物监督
心血管医学心血管医学
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

矿物质皮质类受体抗剂 (MRAs),包括螺旋,eplerenone和finerenone,对于心脏保护和保护至关重要.
这些MRA的真实世界比较安全数据有限,需要进一步调查.

研究的目的:

为了比较 spironolactone,eplerenone 和 finerenone 的不良事件 (AE) 概况.
用FAERS数据在现实环境中识别与每个MRA相关的特定安全问题.

主要方法:

从2004年第一季度到2024年第四季度,对美国FDA不良事件报告系统 (FAERS) 数据进行了回顾性分析.
使用四种不成比例的方法 (ROR,PRR,BCPNN,MGPS) 来检测AE信号.
专注于关键的安全问题:高血,功能障碍,性副作用和先天异常.

主要成果:

总共分析了8,625份关于螺旋乳的AE报告,2,045份关于eplerenone的AE报告,以及1,391份关于finerenone的AE报告.
超血症和急性损伤是螺旋和eplerenone的常见副作用.
费内伦显示出强烈的信号,表明球膜过率下降和高血症,与螺旋和螺旋相比,与性激素相关的副作用较少.

结论:

螺旋乳,eplerenone和finerenone具有不同的AE配置文件,高胆血症和功能障碍是常见的担忧.
螺旋乳与独特的荷尔蒙和发育副作用有关.
费内伦可能在与雄激素相关的副作用方面提供更安全的概况,这需要进一步的临床验证.

关键词:

在FAERS数据库中,我们可以找到FAERS数据库.不良事件信号不良事件信号数据挖掘是数据挖掘的一个方法.不成比例性分析分析矿物质皮质类受体对手 (MRAs)安全分析安全分析.

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