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相关概念视频

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Centrosome Duplication02:25

Centrosome Duplication

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The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
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Gene Duplication and Divergence02:37

Gene Duplication and Divergence

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The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
7.9K
Elements and Compounds01:27

Elements and Compounds

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Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
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Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

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The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
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Periodic Classification of the Elements04:00

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The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
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Updated: Jan 24, 2026

Quantifying the Activity of cis-Regulatory Elements in the Mouse Retina by Explant Electroporation
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Quantifying the Activity of cis-Regulatory Elements in the Mouse Retina by Explant Electroporation

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分段重复的监管元素经历了人类特异性的重新布线.

Seth Weaver, Craig B Lowe

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    概括
    此摘要是机器生成的。

    分段重复通过建立非编码元素的家族来创建基因调节网络. 这些元素可以重新连接,影响基因调节和推动进化变化,特别是在人类特定的环境中.

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    科学领域:

    • 基因组学就是基因组学.
    • 进化生物学 进化生物学
    • 基因规则 基因规则

    背景情况:

    • 基因调控创新驱动着表型进化.
    • 可转换的元素是已知的cis-regulatory元素家族的驱动因素.
    • 了解共同监管网络形成的新机制至关重要.

    研究的目的:

    • 确定超出可转化要素的共同监管网络的机制.
    • 根据序列相似性和细胞类型特定活性分析调节元素家族.
    • 调查细分重复在创建和修改监管网络中的作用.

    主要方法:

    • 应用序列相似性和染色质可访问性分析到人类T2T基因组组合和ESC数据.
    • 使用STARR-seq进行监管元素网络的功能验证.
    • 使用CRISPRi识别ESC中验证的监管元素的目标基因.

    主要成果:

    • 细分重复是一个主要的机制,在社会经济委员会中创建了超过一千个监管要素网络.
    • 功能验证证实这些网络是监管元素家族.
    • 复制后,调控元素表现出目标基因关系的维护和重新连接,包括新的远距离和间位调节.
    • 许多重新布线事件都是人类特有的.
    • 分段重复不成比例地扩大了免疫细胞和特定大脑区域的调节元素.

    结论:

    • 分段重复是基因调节创新的重要来源.
    • 复制后的调节性重新连接有助于基因调节性进化.
    • 监管元素的新功能化可能会在重复后通过新的基因组背景来促进.