Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Emerging Adulthood01:27

Emerging Adulthood

648
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
648
Protein and Protein Structure02:15

Protein and Protein Structure

87.1K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
87.1K
Random Error01:04

Random Error

9.1K
Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.1K
Random Variables01:09

Random Variables

17.6K
A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
17.6K
Randomized Experiments01:13

Randomized Experiments

8.9K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
8.9K
Random and Systematic Errors01:20

Random and Systematic Errors

14.6K
Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
14.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A case report: A man creates holes in his own heart.

Journal of family medicine and primary care·2026
Same author

Targeting amino acid metabolism in hepatocellular carcinoma.

Trends in molecular medicine·2026
Same author

The emergence of novel versus known three-dimensional structures from random sequences.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Author Correction: High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs.

Nature chemistry·2026
Same author

Design of an ultrabright biosensor for dynamic imaging of kinase activity in cells.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Emergence of specific binding and catalysis from a designed generalist binding protein.

Nature chemistry·2026

相关实验视频

Updated: Jan 24, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.0K

从随机序列中出现的小说与已知的三维结构的出现

Rose Yang, Hyunjun Yang, Anton Davydenko

    bioRxiv : the preprint server for biology
    |January 23, 2026
    PubMed
    概括

    蛋白质中重复的随机序列比随机序列更有可能折叠成稳定的结构,这支持了蛋白质进化理论. 这项研究有助于理解蛋白质折叠和设计新的蛋白质.

    科学领域:

    • * 计算生物学和生物信息学
    • * 分子进化和蛋白质设计

    背景情况:

    • * 随机蛋白序列通常不太可能折叠成稳定,功能性的结构.
    • * 假设表明,重复序列可能会克服这种限制,影响蛋白质进化.

    研究的目的:

    • * 为了研究由重复的随机段组成的蛋白质序列的折叠性.
    • * 探索这些预测的蛋白质折叠的结构多样性和稳定性.
    • * 用实验方法验证计算预测.

    主要方法:

    • *采用蛋白质结构预测算法来分析120个残留序列,随机重复的长度各不相同 (5-60个残留).
    • *研究了插入和删除 (INDEL) 对预测的蛋白质结构的影响.
    • * 采用循环二元化 (CD) 光谱学和X射线晶体学进行新型结构的实验验证.

    主要成果:

    • *重复次数<30个残留的序列显示高折叠信心 (1-12%).
    • *观察到常见的折叠,如β-solenoids和螺旋捆,包括新的α-螺旋螺丝结构.
    • *实验验证证了一种新型超二次结构的稳定性和结构.

    结论:

    • * 蛋白质结构预测工具可以在训练数据分布之外识别折叠.

    更多相关视频

    Sequencing of mRNA from Whole Blood using Nanopore Sequencing
    11:26

    Sequencing of mRNA from Whole Blood using Nanopore Sequencing

    Published on: June 3, 2019

    14.7K
    Three-Dimensional Shape Modeling and Analysis of Brain Structures
    05:33

    Three-Dimensional Shape Modeling and Analysis of Brain Structures

    Published on: November 14, 2019

    7.6K

    相关实验视频

    Last Updated: Jan 24, 2026

    Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
    09:51

    Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

    Published on: July 16, 2017

    16.0K
    Sequencing of mRNA from Whole Blood using Nanopore Sequencing
    11:26

    Sequencing of mRNA from Whole Blood using Nanopore Sequencing

    Published on: June 3, 2019

    14.7K
    Three-Dimensional Shape Modeling and Analysis of Brain Structures
    05:33

    Three-Dimensional Shape Modeling and Analysis of Brain Structures

    Published on: November 14, 2019

    7.6K
  • *与随机序列相比,重复序列显著增加了蛋白质折叠的可能性.
  • *研究结果支持通过短序列的重复和分类来支持蛋白质进化理论,并对蛋白质设计产生影响.