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相关概念视频

Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

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Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
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Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

3.7K
Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
3.7K
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

3.9K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
3.9K
Joints01:26

Joints

35.5K
Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
35.5K
Introduction to Joints00:58

Introduction to Joints

4.7K
The adult human body usually has 206 bones, and except for the hyoid bone in the neck, each bone is connected to at least one other bone. Joints are the location where bones come together. Many joints allow for movement between the bones. At these joints, the articulating surfaces of the adjacent bones can move smoothly against each other. However, the bones of other joints may be joined by connective tissue or cartilage. These joints are designed for stability and provide little or no...
4.7K
Ankle Joint01:10

Ankle Joint

2.9K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
2.9K

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Updated: Jan 24, 2026

Mining Spatial Transcriptomics Datasets using DeepSpaceDB
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组织病理学和空间转录学联合绘制了mTORC1驱动肌肉病变的肌纤维特异性病理程序.

Jer-En Hsu, Qingyang Zhao, Weiqiu Cheng

    bioRxiv : the preprint server for biology
    |January 23, 2026
    PubMed
    概括

    通过使用Seq-Scope将基因病理与分子状态联系起来,可以更好地理解骨肌肉肌病. mTORC1过度激活会导致明显的纤维类型依赖的肌肉病理和非肌细胞积累.

    科学领域:

    • 肌肉生物学 肌肉生物学
    • 分子病理学分子病理学
    • 系统生物学 系统生物学

    背景情况:

    • 肌肉病症是各种各样的肌肉疾病,其机制尚不清楚,部分原因在于,在单纤维分辨率下将组织病理与分子状态的联系受到限制.
    • 了解这些机制需要先进的技术来分析异质肌肉组织.

    研究的目的:

    • 为了研究驱动肌肉病理的分子机制,在mTORC1过度激活的动物模型中.
    • 通过使用空间转录学,在单纤维分辨率下将基因病理特征与分子状态联系起来.

    主要方法:

    • 应用了高分辨率的Seq-Scope空间转录组学到动物的延伸指长长肌 (EDL) 和单肌 (SOL) 肌肉.
    • 分析了纤维类型对mTORC1过活化和非肌细胞群的特定反应.

    主要成果:

    • mTORC1过度激活诱导了骨肌肉中不同的,纤维类型依赖的病理程序.
    • IIx型纤维呈现出相反的命运:SOL中的缩和EDL中的巴索菲利亚.
    • IIb型纤维呈现异质性,包括应激反应和发育重编程.
    • 非肌细胞,如巨细胞和纤维细胞,在SOL中积累,促进纤维化和炎症.

    结论:

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    • 持续的mTORC1信号通过不同的代谢和结构途径破坏肌肉平衡.
    • 这项研究将基因病理现象类型与单纤维分辨率的分子状态联系起来,推动了肌肉病研究.