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Updated: Jan 24, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
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Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Published on: October 30, 2015

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评估CD8/CD4对T细胞功能的影响,以TCR-pMHC-核受体捕捉和滑动键的形式

Stefano Travaglino, Amir Hossein Kazemipour Ashkezari, Menglan Li

    bioRxiv : the preprint server for biology
    |January 23, 2026
    PubMed
    概括

    基于力量的T细胞受体 (TCR) 与-MHC (pMHC) 键的相互作用,特别是与CD4/CD8等核心受体的相互作用,比传统的亲和度测量更好地预测T细胞激活. 核心受体的参与通过捕获纽带机制提高了TCR的敏感性和特异性.

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