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Updated: Jan 24, 2026

Characterizing Mutational Load and Clonal Composition of Human Blood
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Published on: July 11, 2019

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延长寿命的胰岛素信号的下调减少了生殖系突变负载

Elizabeth M L Duxbury, Alice M Godden, Jean-Charles de Coriolis

    bioRxiv : the preprint server for biology
    |January 23, 2026
    PubMed
    概括

    在成年期减少胰岛素/IGF-1信号传导 (IIS) 会延长寿命,并保护生殖基因组免受突变,但需要HRDE-1蛋白来产生这种保护作用.

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