相关实验视频

Updated: Jan 24, 2026

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome

Published on: March 31, 2023

瘤免疫疗法和微生物组:从长椅到床边的应用

Anqi Lin¹, Minying Xiong¹, Aimin Jiang²

¹Department of Oncology Zhujiang Hospital, Southern Medical University Guangzhou China.

|January 23, 2026

概括

人类微生物组通过调节瘤免疫微环境,显著影响癌症免疫疗法的有效性. 了解这些微生物机制可以导致基于微生物的精确免疫疗法策略.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
在瘤学瘤学.

背景情况:

癌症免疫疗法为传统治疗提供了一个有希望的替代方案,但药物耐药性等挑战仍然存在.
人类微生物组在调节免疫反应和影响免疫疗法疗效方面的作用越来越被认可.
基于微生物组的癌症治疗的机制和转化潜力需要进一步探索.

研究的目的:

系统地审查多种微生物如何影响瘤免疫微环境.
阐明微生物特征对免疫检查点抑制剂 (ICI) 和CAR-T细胞疗法的反应的预测价值.
突出新兴的基于微生物组的干预措施,以获得与免疫疗法的协同效应.

主要方法:

系统审查关于微生物和瘤免疫微环境的科学文献.
分析微生物调节机制,包括代谢物,免疫细胞原始化和抗原仿真.
讨论预测性微生物特征和干预策略,如便微生物组移植 (FMT),益生菌和工程细菌.

主要成果:

来自各种解剖部位的微生物和内微生物调节瘤免疫微环境.
特定的微生物特征可以预测患者对免疫检查点抑制剂 (ICI) 和CAR-T细胞治疗的反应.
干预策略,如FMT,益生菌和工程细菌,显示出与免疫治疗的协同潜力.

结论:

整合机械洞察力和翻译进步为基于微生物的精密免疫疗法提供了基础.
准微生物组可以提高免疫治疗的疗效,改善患者的生存率,并减少不良事件.
对微生物组与宿主相互作用的进一步研究对于开发新的癌症治疗策略至关重要.

关键词:

癌症癌症癌症癌症癌症免疫检查点抑制剂免疫检查点抑制剂免疫疗法免疫疗法微生物组是一个微生物组.瘤微环境是一个微环境.

更多相关视频

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Photoluminescence: Applications

Photoluminescence: Applications

Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...

Radiation: Applications

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...

Applications of Stress

Applications of Stress

Consider a structure made of a boom and a rod designed to support a load. These two components are connected by a pin and stabilized by brackets and pins. The boom and the rod are detached from their supports to assess the different stresses imposed on this structure, and a free-body diagram is drawn. Then, all the forces applied, including the load acting on the structure, are identified. The reaction forces exerted on both the boom and the rod are computed using the equilibrium equations.
The...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...