在患有多发性硬化症的人群中周围血管空间的扩散张力成像和疾病进展:为期5年的纵向MRI研究
Ashley Tranquille1, Robert Zivadinov1,2, Bianca Weinstock-Guttman3
1Department of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA.
Brain communications
|January 23, 2026
概括
在周血管空间 (DTI-ALPS) 上的扩散张力图像分析显示了预测复发性复发性多发性硬化症 (pwRRMS) 中残疾进展的前景. 较低的基线DTI-ALPS与证实残疾进展 (CDP) 和 pwRRMS中独立于复发活动的进展 (PIRA) 有关.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 在周周血管空间 (DTI-ALPS) 上的扩散张力图像分析已被探索在多发性硬化症 (MS) 中的淋巴功能.
- 对DTI-ALPS和MS (pwMS) 患者的残疾进展的长度研究有限.
- 以前的横截面研究表明,DTI-ALPS与 pwMS 中的残疾之间存在关联.
研究的目的:
- 在患有复发性复发性多发性硬化症 (pwRRMS) 和渐进性多发性硬化症 (pwPMS) 患者中,研究DTI-ALPS与已确认的残疾进展 (CDP) 和不依赖复发活动的进展 (PIRA) 的纵向关联.
- 评估DTI-ALPS在pwRRMS和pwPMS中预测5年和10年的残疾进展中的价值.
- 探索DTI-ALPS是否提供超出一般疾病负担的独立预测价值,例如正常出现的白质 (NAWM) 平均扩散度 (MD).
主要方法:
- 一项纵向研究涉及72个 pwRRMS,27个 pwPMS和23个健康对照 (HC) 在基线和5年后进行3T MRI扫描.
- 自动化DTI-ALPS指数计算使用模板定义的ROI,不包括T2超强度.
- 5年和10年的CDP和PIRA评估,使用ANCOVA和多变量后勤回归进行统计比较,对NAWM MD和基线T2-LV进行控制.
主要成果:
- 基线DTI-ALPS在pWMS中低于HCs,但在控制NAWMMD后,这种差异减少了.
- 在pwRRMS中,较低的基线DTI-ALPS与5年和10年的CDP和PIRA显著相关,特别是在对NAWMMD进行控制时.
- 在pwPMS组中没有发现任何显著的关联,在5年内DTI-ALPS的变化与MS组中的任何一个进展都没有相关.
结论:
- 基线DTI-ALPS降低与pWRRMS的未来残疾进展有关,这表明其作为预后标记物的潜力.
- 在pwPMS中,DTI-ALPS的信息可能不那么丰富,这表明它的有用性可能取决于疾病的阶段.
- 虽然 pwMS 和 HC 之间的初始 DTI-ALPS 差异受到 NAWM MD 的影响,但基线 DTI-ALPS 保留了对 pwRRMS 长期进展的预测价值.
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