识别多个预后生物标志物集用于SKCM中的风险分层
Shivani Malik1, Ritu Tomer1, Akanksha Arora1
1Department of Computational Biology, Indraprastha Institute of Information Technology, New Delhi, India.
Frontiers in bioinformatics
|January 23, 2026
概括
多个基因表达生物标记集准确地预测皮肤皮肤黑色素瘤 (SKCM) 的预后,为单个签名提供了灵活的替代方案. 这种方法提高了高风险患者的预后准确性和临床适用性.
科学领域:
- 基因组学和生物信息学
- 癌症研究 癌症研究
- 计算生物学 计算生物学
背景情况:
- 目前用于癌症预后的转录组学研究通常依赖于单个生物标志物集,这可能会限制它们在不同患者群体中的有效性.
- 皮肤皮肤黑色素瘤 (SKCM) 预后从准确的预测模型中受益,但单一的方法可能无法捕捉到疾病的复杂性.
- 识别多个独立的预后生物标志物集对于提高癌症预测工具的稳定性和适用性至关重要.
研究的目的:
- 开发和验证基于机器学习的预后模型,用于预测皮肤皮肤黑色素瘤 (SKCM) 患者的1年,3年和5年的总生存期.
- 识别多个独立的基因表达预后生物标志物组,用于SKCM.
- 为了评估这些独特的生物标志物的性能和外部有效性,可以预测患者的结果.
主要方法:
- 开发了使用SKCM基因表达数据的机器学习分类器,以预测患者的生存率.
- 采用先进的特征选择技术来识别每组20个预后生物标志物的七个不同的组,确保组之间没有重叠.
- 在独立测试和GEO数据集 (GSE65904) 上使用曲线下的面积 (AUC) 和科恩的卡帕指标验证模型性能.
主要成果:
- 主要的20基因生物标志物组实现了AUC为0.90,卡帕为0.58.
- 七个独立的生物标志物集显示出强大的预测性能,AUC从0.84到0.91不等,卡帕值从0.48到0.64.
- 对GSE65904的外部验证证实了预测效用,主要组的AUC为0.83,第三组为0.86.
结论:
- 单一的基因表达特征不足以准确的SKCM预后;多个独立的生物标志物集提供了更灵活和可靠的方法.
- 在多个生物标志物集中一致的高性能表明了开发的方法的稳定性和强度.
- 外部验证和公共数据/代码可访问性 (https://github.com/raghavagprag/skcm_prognostic_biomarker) 支持这些黑色素瘤预测工具的可靠性和潜在的更广泛应用.
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