暴露于寒冷和心血管系统:从生理适应到病理风险
Yao Li1,2, Jiawei Wu2, Yinli Xu2
1College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China.
Frontiers in physiology
|January 23, 2026
概括
寒冷压力在心血管医学中呈现出一种悖论,它既是危险又是治疗机会. 了解寒冷的感受 了解寒冷的感受
科学领域:
- 心血管医学 心血管医学
- 环境生理学环境生理学
- 代谢适应 代谢适应
背景情况:
- 暴露于寒冷是心血管事件的已知危险因素.
- 身体对寒冷的反应涉及复杂的生理适应.
- 这些适应可以对心血管健康有害和有保护作用.
研究的目的:
- 批判性地分析寒冷压力在心血管医学中的矛盾作用.
- 综合当前关于心血管对寒冷反应的证据.
- 提出季节性心血管疾病调节的模型,并探索基于寒冷的疗法.
主要方法:
- 审查现有的关于寒冷压力和心血管疾病的文献.
- 综合来自对冠状动脉疾病和心力衰竭研究的证据.
- 对参与寒冷适应的分子途径的分析.
主要成果:
- 寒冷的挑战触发了同情激活,血液动力学压力和棕色脂肪组织的招募.
- 心脏代谢重塑发生在对寒冷的反应中,具有潜在的病理或保护性结果.
- 有证据表明,分子途径影响了代谢,炎症和电生理学效应.
结论:
- 寒冷压力在心血管医学中表现出双重作用,呈现出风险和适应机制.
- 了解这些适应机制,如棕色脂肪组织激活,可能提供治疗潜力.
- 基于感冒的影响,可以开发季节性心血管疾病调节的机制模型.
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