在肝细胞癌患者中与贝瓦西祖马布相关的胃肠道穿孔:病例报告
Yi-Jie Wang1, Kuo-Feng Hsu1, Guo-Shiou Liao1
1Division of General Surgery, Department of Surgery, Tri Service General Hospital, National Defense Medical University, Taipei, Taiwan.
Case reports in oncology
|January 23, 2026
概括
一名接受阿特佐利祖马布-贝瓦齐祖马布治疗晚期肝癌的患者在手术后出现胃穿孔,尽管治疗中断了5周. 这种罕见的并发症强调了在肝细胞癌患者接受抗VEGF治疗后需要谨慎的手术时间.
科学领域:
- 肝细胞癌 (HCC) 治疗方法
- 癌症治疗的胃肠道并发症
- 免疫疗法和向药物组合
背景情况:
- 阿特佐利祖马布加贝瓦齐祖马布是高级肝细胞癌 (HCC) 的标准一线治疗方法.
- 贝瓦西祖马布是一种抗VEGF疗法,具有罕见的胃肠道穿孔风险.
- 贝瓦西祖马布诱导的穿孔的确切机制和最佳的手术时间仍然是令人担忧的领域.
研究的目的:
- 报告HCC患者肝切除术后胃穿孔的病例,这些患者接受了阿特佐利祖马布-贝瓦西祖马布治疗.
- 讨论这种罕见并发症的潜在机制和影响.
- 强调在接受联合免疫疗法和抗VEGF治疗的患者中个性化术后管理的重要性.
主要方法:
- 一个62岁的女性患有复发性HCC的病例报告.
- 患者接受了阿特佐利祖马布和贝瓦齐祖马布,随后进行了肝切除术.
- 对术后并发症进行了监测,从而诊断和治疗胃穿孔.
主要成果:
- 患者在术后第六天出现胃穿孔,尽管在手术前停止服用贝瓦齐祖马布5周.
- 穿孔成功地通过出现的腹腔切除术和初级修复来管理.
- 这一案例强调了严重的胃肠道并发症的潜力,即使有显著的手术前治疗中断.
结论:
- 与贝瓦西祖马布相关的胃肠道穿孔是HCC治疗中罕见但严重的并发症.
- 个性化的术后管理和对抗VEGF治疗后手术时间的仔细考虑至关重要.
- 在先进的癌症治疗时代,多学科评估对于优化患者护理至关重要.
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