确定犬类ROTEM Sigma参考范围,并与ROTEM Delta进行比较分析
Aurélie Jourdan1,2, Julia Noval Montero1,2, Geoffrey Troussier1,2
1Centre Hospitalier Vétérinaire Frégis, Paris, France.
Frontiers in veterinary science
|January 23, 2026
概括
这项研究为狗的ROTEM Sigma分析仪建立了新的参考间隔,改善了静血功能障碍评估. 最大凝块坚固度 (MCF) 受体重,性别和血小板计数的影响.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 血液学 血液学 血液学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 血液静止功能障碍在重症狗中很常见,影响结果.
- 传统的凝血试验对复杂的体内血液静止有有限的洞察力.
- 粘弹性测试,如旋转性血栓弹性测量 (ROTEM),评估全血凝块的动态.
研究的目的:
- 为ROTEM Sigma平台建立特定于犬类的参考间隔.
- 将ROTEM Sigma数据与现有的ROTEM Delta值进行比较.
- 研究生理变量对ROTEM参数的影响.
主要方法:
- 对42只健康的狗进行前性观察研究.
- 使用ROTEM Sigma EXTEM,INTEM,FIBTEM和HEPTEM测试对全血进行分析.
- 使用参数和中位数-MAD方法生成参考间隔;多变量回归分析.
主要成果:
- 对于所有ROTEM西格玛参数 (CT,CFT,A10,MCF,LI60,G) 的定义参考间隔.
- EXTEM的结果与ROTEM的Delta数据有很好的一致性;INTEM和FIBTEM的数据有所不同.
- 最大凝块坚固度 (MCF) 受到体重,血小板数和性别的显著影响.
结论:
- 建立了狗的ROTEM Sigma参考间隔,提高了临床效用.
- 证明了跨平台的一致性 (特别是EXTEM),同时强调了Sigma特定的范围.
- 确定了MCF的关键生物决定因素,有助于解释静血功能.
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