延长长期随访和Stop Imatinib研究的生存率
François-Xavier Mahon1,2, Stéphanie Dulucq3,2, Delphine Réa4,2
1Département d'Hématologie, Institut Bergonié, University of Bordeaux, INSERM, UMR1312, Bordeaux, France.
Blood neoplasia
|January 23, 2026
概括
在患有持续分子反应的慢性髓性白血病 (CML) 患者中中止伊马替尼是可行的. 长期随访没有显示CML进展,支持无治疗缓解的可能性.
科学领域:
- 血液学 血液学 血液学
- 临床瘤学临床瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 法国Stop Imatinib (STIM1) 研究调查了慢性髓性白血病 (CML) 患者中断伊马替尼的情况.
- 患者获得了持续的分子反应 (BCR::ABL1的≥4.5-log降低).
- 严格的标准定义了分子复发 (MRec).
研究的目的:
- 介绍STIM1研究的长期随访数据.
- 评估在CML患者中停止伊马替尼的安全性和可行性.
- 为了评估停药后的长期缓解和生存结果.
主要方法:
- 对STIM1研究参与者的长期随访.
- 平均分子随访时间为12.8年 (范围为0.8-15年).
- 分子无复发生存率和整体生存率的分析.
主要成果:
- 分子无复发生存率在120个月后为37%,在药物停用后156个月后为35%.
- 在延长后续期间,没有患者出现CML进展.
- 总体生存率为97%在10年和88%在20年.
结论:
- 停止伊马替尼布治疗是CML患者持续分子反应的安全和可行的选择.
- 在停止伊马替尼布后,可以维持长期缓解和生存.
- 观察到晚期分子复发,确认为原始疾病的持续性.
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