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有机-无机混合纳米纤维膜通过电:工程特征和细胞兼容性

Soraia A R Coelho¹, Liliana Grenho², Maria Helena Raposo Fernandes²

¹CICECOMaterials Institute of Aveiro, Department of Materials and Ceramic Engineering, University of Aveiro, 3810-193 Aveiro, Portugal.

ACS applied polymer materials

|January 23, 2026

概括

这项研究开发了用于组织工程的环保有机-无机混合纤维支架. 优化的支架显示了增强的机械性能,生物活性和细胞相容性,特别是较小的纤维直径.

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
材料化学材料化学

背景情况:

有机-无机 (O/I) 混合纤维支架是模仿组织工程中细胞外基质 (ECM) 的先进材料.
开发生物相容和生物活性支架对于有效的组织再生至关重要.

研究的目的:

通过环保的sol-gel工艺创建O/I混合纤维支架,使用酸和聚烯酸 (PCL).
调查电旋参数对脚手架形态,纤维直径和整体性能的影响.
评估用于组织工程应用开发的O/I混合支架的机械,物理和生物性能.

主要方法:

用一个环保的"in situ"sol-gel工艺合成了O/I混合材料.
使用电来制造纳米纤维地毯,并优化了关键参数 (距离,流速,电压).
制造和表征了两种具有不同纤维直径 (∼65 nm 和 ∼116 nm) 的支架.
进行了机械测试,表面分析 (可湿性,无性形成),体外细胞降解和细胞增殖/细胞相容性测试.

主要成果:

确定了最佳的电旋条件 (12厘米距离,125-150微升·小时-1流量,14-17千伏电压).
在PCL矩阵内实现了无机相的均分布,证实了结相互作用.
与整洁的PCL相比,O/I混合脚手架表现出增强的机械性能 (Young的模量,拉力强度),改善的水友性,以及优越的可降解性和生物活性 (apatite形成).
纤维直径较小的支架 (∼65 nm) 显示出更高的机械强度和更好的细胞相容性,促进细胞增殖.

结论:

开发的O/I混合纤维支架为组织工程提供了一个可持续和有效的平台.
优化电参数可以控制纤维形态和直径,显著影响脚手架性能.
这些绿色O/I混合物的增强生物活性,机械完整性和细胞兼容性将它们定位为生物纳米混合应用的下一代有希望的生物材料,特别是在组织再生中.

关键词:

电力旋转是指电力旋转.绿色路线是绿色的路线.在位溶液凝.有机 - 无机混合膜.物理 - 机械性质.聚卡普罗拉克托尼是一种多种类型的蛋白质.

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