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尾切除术史与肠道微生物群组成之间的关联:一个后续的横截面研究

Matija Hadžić¹, Paul Hammer², Carsten Krumbiegel²

¹University Hospital Sveti Duh, Zagreb, Croatia.

Frontiers in microbiology

|January 23, 2026

概括

尾切除术会影响肠道微生物群,特别是在不健康的个体中. 尾切除术或没有尾切除术的健康个体没有显著的肠道微生物群差异,这表明尾对健康成年人的肠道健康可能并不至关重要.

科学领域:

微生物组研究的研究.
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

尾被认为是一个调节性免疫器官,也是肠道微生物群的储存库.
尾切除术与潜在的健康风险有关,但其对肠道微生物群的具体影响尚未完全理解.

研究的目的:

研究尾切除术对肠道微生物群组成和功能的影响.
为了比较肠道微生物群的个人之间的个人和没有尾切除的历史,包括健康和不健康的队列.

主要方法:

一项追溯的横截面后续研究,分析来自欧洲实验室数据库的肠道微生物群数据.
比较包括尾切除术和没有尾切除术的受试者 (wA vs. noA),尾切除术和没有尾切除术的健康受试者 (HwA vs. HnoA),以及尾切除术的健康与非健康受试者 (HwA vs. nHwA).
分析涉及alpha和beta多样性,类,属和代谢途径的相对丰富性,年龄,BMI和性别作为共变量.

主要成果:

在尾切除术和没有尾切除术的个体之间观察到肠道微生物群组成和功能上的显著差异 (wA与noA).
在尾切除和没有尾切除的健康个体之间没有发现显著的肠道微生物群差异 (HwA与HnoA).
在接受尾切除术的健康和不健康个体之间发现了显著的差异 (HwA vs. nHwA),不健康的组表现出减少的多样性和较低的特定属的丰度 (Eubacterium ruminantium,Lachnospiraceae FCS020).

结论:

尾切除术显著改变肠道微生物群的组成,特别是在非健康的个体中.
在健康个体中,尾切除似乎不会显著影响肠道微生物群的多样性或组成.
需要进一步的研究,以了解尾切除术后肠道微生物群的长期恢复能力.

关键词:

尾切除术是指尾切除术.附录是附录中的附录.这种疾病叫做dysbiosis.我们的肠道细菌是肠道细菌.我们的肠道微生物群.在术后的术后生活.恢复性趋势的恢复性趋势

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