血中阿尔多与雷宁比率升高作为左心室逆转型的潜在风险标志物:一个横截面研究
Mingjie Xu1,2, Yushuang Wei2,3, Mingli Li2
1Department of Urology, Hunan University of Medicine General Hospital, Huaihua, Hunan, China.
Frontiers in medicine
|January 23, 2026
概括
过高的阿尔多与素比率 (ARR) 与中国成年人的左心室 (LV) 重塑和LV缩 (LVH) 风险增加有关. 使用矿物质皮质体受体抗剂 (MRAs) 的早期干预可能是有益的.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 高血压研究 高血压研究
背景情况:
- 主要的阿尔多斯特主义 (PA) 是二次高血压的主要原因.
- 动脉与不良的左心室 (LV) 改造有关.
- 阿尔多与因比 (ARR) 与中国人群中的LV重塑之间的关联尚未研究.
研究的目的:
- 调查ARR,血中阿尔多素度 (PAC) 和血内氨酸度 (PRC) 与不良LV重塑的关联.
- 在中国队列中评估与ARR相关的LV缩 (LVH) 风险.
主要方法:
- 来自中国广西两家医院的724名参与者的回顾性分析 (2022年9月 - 2024年3月).
- 收集的数据包括人口统计,临床病史,药物,阿尔多斯特-氨酸测试和心声回声.
- 用通用线性模型 (GLM) 和多变量逻辑回归来分析ARR,PAC,PRC和LV重塑/LVH之间的关系,包括剂量反应分析.
主要成果:
- ARR与左心脏大小增加,LV终端-透气直径,LV质量和LV质量指数相关.
- 一个SD增加ARR显著预测LVH发生 (OR=1.531,p=0.030).
- 与最低三位数相比,ARR的最高三位数显示LVH的风险增加了2.106倍 (p趋势<0.05),特别是在不接受MRA的参与者中. 观察到ARR和LVH风险之间存在显著的剂量反应关系 (总体p<0.001).
结论:
- 升高的ARR与不良LV重塑和LVH的风险增加有关,可能发生在当前临床查值以下.
- ARR可能是心脏结构变化的早期指标.
- 使用矿物质皮质体受体抗剂 (MRA) 的早期干预可能是有益的,这需要进一步的前性和干预性研究.
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