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在老鼠模型中,对由肥胖引起的类类精子,生殖毒素及其组合的综合量化

Yunlong Yao^1,2, Xi Zhang^1,2, Lingru Li²

¹School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

|January 23, 2026

概括

肥胖和生殖有毒物质通过破坏丸功能,加剧男性不孕不育,卵性精子缺血. 综合暴露会比单个因素造成更严重的伤害,突显了综合研究的必要性.

科学领域:

生殖生物学生殖生物学
毒理学毒理学毒理学
代谢障碍代谢障碍代谢障碍

背景情况:

奥利戈阿斯动物精子缺陷是男性不孕症的关键原因,与肥胖和生殖毒素的增加有关.
这些因素对男性生殖健康的综合影响尚不清楚.

研究的目的:

研究肥胖和生殖毒素对男性生殖功能的独立和协同影响.
建立和比较由高脂肪饮食 (HFD),Tripterygium wilfordii糖化物 (GTW) 和它们的组合 (HFD + GTW) 诱导的小鼠精的模型.

主要方法:

开发了三种不同的老鼠模型:GTW诱导的毒性,HFD诱导的代谢功能障碍和HFD+GTW联合暴露.
在12周内系统评估体重,代谢指数,性激素,精子质量,丸组织病理学,肠道微生物群和丸转录组.
定量实时PCR用于验证转录组发现.

主要成果:

无论是GTW还是HFD,都独立地降低了精子质量,并引起了荷尔蒙乱和丸损伤.
组合的HFD+GTW模型显示显著恶化生殖功能障碍,包括严重的精子细胞损失和丸结构破坏.
多组学分析揭示了肠道微生物群和丸基因表达的协调变化,表明代谢和炎症途径之间的相互作用.

结论:

建立了可靠的老鼠模型,用于单个和组合的橄酸和动物精子病因.
肥胖和GTW毒性之间的相互作用通过代谢和炎症途径加剧丸损伤.
这项研究为进一步研究男性不孕症的机制和潜在治疗方法提供了一个平台.

关键词:

肠的轴.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖这种情况是Oligoasthenozoospermia.生殖有毒物质生殖有毒物质翻译学翻译学翻译学翻译学

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