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Updated: Jan 24, 2026

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神经纤维光链作为多发性硬化症 (LUMINOUS) 疾病活动的替代候选人-随机对照试验的元回归

Roxanne Pretzsch1, Sahla El Mahdaoui2, Poljanka Johnson3

  • 1Multiple Sclerosis Centre, Departments of Neurology, Clinical Research and Biomedicine, University Hospital Basel and University of Basel, Switzerland; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Switzerland; Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Switzerland.

Multiple sclerosis (Houndmills, Basingstoke, England)
|January 23, 2026
PubMed
概括

神经纤维光链 (NfL) 在多发性硬化症 (MS) 临床试验中显示了对复发率,MRI病变和残疾恶化的治疗效果的中度关联. 然而,没有发现与大脑体积变化有一致的联系.

关键词:
神经光纤光链链是什么意思这是一种元回归 (meta-regression).多发性硬化症多发性硬化症随机对照试验是随机对照试验.替代体标志物替代体标志物

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