bensodiazepines的使用和发生2型糖尿病的风险在一般人群中失眠
Tingting Zhao1, Chang Liu1, Shiyu Zhu1
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, State Key Laboratory of Transvascular Implantation Devices, Heart Regeneration and Repair Key Laboratory of Zhejiang Province, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China.
CNS & neurological disorders drug targets
|January 23, 2026
概括
bensodiazepine (BDZ) 的使用不会增加2型糖尿病 (T2DM) 风险在失眠的人. 这一发现得到了观察和遗传数据的支持,表明BDZ处方在这个人群中具有长期的代谢安全性.
科学领域:
- 药理学和内分泌学 药理学和内分泌学
- 代谢性疾病研究研究
- 睡眠医学 睡眠医学
背景情况:
- 失眠是已知的2型糖尿病 (T2DM) 的风险因素.
- 类药物 (BDZs) 经常被处方用于失眠,但它们对T2DM风险的影响尚不清楚.
- 关于BDZ使用与失眠患者发生的T2DM之间存在联系的证据有限.
研究的目的:
- 在一组失眠的个体中调查使用二 (BDZ) 和患2型糖尿病 (T2DM) 的风险之间的关联.
- 评估BDZ药理目标和T2DM之间的潜在因果关系.
- 提供关于BDZs在失眠患者的长期代谢安全性的证据.
主要方法:
- 利用英国生物库的潜在队列,包括报告失眠的参与者.
- 采用多变量调整的考克斯回归模型和灵敏度分析 (倾向性得分匹配,治疗权重的逆概率,竞争风险分析).
- 进行药物标孟德尔随机化,以探索BDZ标和T2DM之间的因果关系.
主要成果:
- 在14.3年的中位数随访期间,在使用二胺 (BDZ) 和发生2型糖尿病 (T2DM) 的风险之间没有发现显著的关联.
- 敏感性分析始终支持零关联的首要发现.
- 门德尔随机化分析表明,BDZ基因表达对T2DM发展没有显著的因果关系.
结论:
- bensodiazepine (BDZ) 的使用似乎不会对失眠患者的2型糖尿病 (T2DM) 风险产生重大影响.
- 观察和遗传分析的一致结果支持BDZs的代谢安全性.
- 这些发现可能会减轻关于BDZs在临床实践中对失眠管理的长期代谢影响的担忧.
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