在患有自闭症谱系障碍的儿童中,通过tDCS进行静态和动态的低级和高级大脑功能网络调制
Jiannan Kang1, Yuqi Li1, Juanmei Wu1
1Child Rehabilitation Division, Ningbo Rehabilitation Hospital, Ningbo, China.
Developmental neurorehabilitation
|January 23, 2026
概括
跨直流刺激 (tDCS) 在患有自闭症谱系障碍 (ASD) 的儿童中改变了大脑网络组织. 这种神经调节技术影响了静态和动态功能连接,为向治疗提供了潜力.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 计算神经科学是一种神经科学.
背景情况:
- 自闭症谱系障碍 (ASD) 与异常的大脑连接和网络动态有关.
- 跨直流刺激 (tDCS) 对ASD这些网络特征的影响尚未完全理解.
研究的目的:
- 研究tDCS对自闭症儿童静态和动态功能大脑网络组织的影响.
- 探索潜在的神经生理学标记,以指导未来的神经调节策略在ASD.
主要方法:
- 42名患有自闭症的儿童 (年龄为4-6岁) 接受了活跃或假的tDCS.
- 在干预之前和之后,分析了静止状态EEG数据.
- 低序 (LOFC) 和高序功能连接 (HOFC) 网络是使用图形理论和状态构建和分析的.
主要成果:
- 活跃的tDCS在各种频段增加了LOFC和HOFC的强度.
- HOFC显示了特征路径长度的减少和全球/本地效率的提高,特别是在三角波段和三角波段.
- tDCS调制的动态网络转换,通过LOFC和HOFC网络的状态变化来表示.
结论:
- tDCS有效调节了ASD儿童的功能相互作用和动态网络状态.
- 研究结果表明,tDCS对静态和动态大脑网络组织都有影响.
- 结果提供了初步的神经生理学证据,并突出了在ASD中个性化神经调节的潜在基于网络的标志物.
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