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Updated: Jan 24, 2026

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NAD+和Sirt5可以恢复线粒体的生物能量失效,并改善由sucla2突变引起的运动器缺陷

Joy Richard1, Giulia Lizzo1, Noélie Rochat1

  • 1Nestlé Institute of Health Sciences, Nestlé Research, Switzerland.

JCI insight
|January 23, 2026
PubMed
概括

过多的 succinyl-CoA会导致斑马鱼的蛋白质损伤和线粒体问题. 补充NAD+前体可以恢复NAD+水平,通过激活Sirt5.5来改善运动和生存.

关键词:
细胞生物学 细胞生物学遗传性疾病是一种遗传性疾病.代谢过程中的代谢.线粒体中的线粒体.

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