幼儿教育环境中的多菌株益生菌和常见感染:一项随机对照试验
Hafiz Haris Ahmad1,2, Blake Peck1, Daniel Terry1,3,4
1Institute of Health and Wellbeing, Federation University, Ballarat, Australia.
Journal of paediatrics and child health
|January 23, 2026
概括
一种多菌株益生菌显著减少了幼儿早期教育机构的幼儿的胃肠道感染. 虽然它对肠道健康有效,但它没有影响呼吸道感染,这表明有针对性的益处.
科学领域:
- 儿科健康 儿科健康
- 微生物组研究 微生物组研究
- 预防传染病 预防传染病
背景情况:
- 常见的感染在幼儿教育 (ECE) 环境中构成重大负担.
- 益生菌因其调节肠道微生物组和增强免疫反应的潜力而受到探索.
- 有限的研究存在于多菌株益生菌在ECE群体的感染预防.
研究的目的:
- 评估多菌株益生菌在减少儿童中常见感染的发生率方面的疗效.
- 评估益生菌补充剂对胃肠道感染 (GITIs) 和呼吸道感染 (RTIs) 的影响.
- 为了确定益生菌用于预防感染的成本效益,在这个年龄组.
主要方法:
- 一个24周的前性,随机,双盲,安慰剂受控试验.
- 参与了118名ECE环境中的儿童,随机分配给接受5株益生菌 (10亿CFU/天) 或安慰剂.
- 通过每周问卷追踪感染发病率;进行治疗意向分析.
主要成果:
- 在益生菌组与安慰剂组相比,在16周后观察到GITIs的62%减少 (IRR:1.62,p=0.055).
- 在补充8周后,益生菌对GITIs产生了显著的保护作用.
- 没有发现对RTIs的显著影响;益生菌的使用估计节省了与减少GITIs相关的4748澳元的成本.
结论:
- 多菌株益生菌补充剂显示,有可能减少参加ECE的儿童的GITIs.
- 益生菌对RTIs没有显著的影响,尽管记录了大量的感染.
- 建议进行进一步的大规模多臂试验,以证实这些发现并探索更广泛的应用.
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