基因病理特征在儿科乳头甲状腺癌的预后作用:系统性审查和元分析
Luca Canali1, Gian Marco Pace1,2, Camilla Zimello1,3
1Otorhinolaryngology - Head & Neck Surgery Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
Head & neck
|January 23, 2026
概括
甲状腺外延伸 (ETE) 和多焦点性是儿科乳头甲状腺癌 (PTC) 复发的重要预测因素. 侧淋巴结转移并不是儿科PTC患者的可靠预后因素.
科学领域:
- 在瘤学瘤学.
- 儿科内分泌学 儿科内分泌学
- 手术病理学手术病理学
背景情况:
- 乳头甲状腺癌 (PTC) 是儿童最常见的内分泌恶性瘤.
- 了解预后因素对于有效的风险分层和儿科PTC治疗规划至关重要.
研究的目的:
- 评估甲状腺外延伸 (ETE),多焦点性和侧淋巴结转移对分化PTC的儿科患者的生存结果的影响.
- 在这个人群中确定影响无病生存 (DFS) 的关键病理因素.
主要方法:
- 一个系统的审查和元分析,坚持PRISMA声明.
- 聚合危险比率 (HRs) 和95%置信区间 (CI) 被计算出来,以评估病理因素对DFS的影响.
- 包括13项研究,涉及2641名儿科PTC患者.
主要成果:
- 多焦点的发生率为30.7%,ETE为45.4%,侧淋巴结转移 (LNM) 为51.6%.
- 多焦点 (HR:1.86,p=0.002) 和ETE (HR:1.78,p=0.010) 是减少DFS的显著预测因素.
- 侧LNM (HR: 1.77,p=0.161) 没有显示出对DFS的统计学上显著影响.
结论:
- 多焦点和ETE是儿科PTC复发的重要预测因素.
- 侧淋巴结转移并不是儿科PTC的可靠预后因素.
- 这些发现支持为儿科PTC量身定制的风险分层和治疗指南.
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