后生菌和尼古丁胺使用不同的机制来改善皮肤屏障的完整性,炎症和角质细胞分化
Yagiz Pat1, Duygu Yazici1, Huseyn Babayev1
1Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Allergy
|January 23, 2026
概括
来自特定细菌和尼古丁胺 (NAM) 的后生物改善了皮肤屏障功能,并减少了人体皮肤的炎症. 这些发现凸显了它们在增强皮肤健康和再生方面的潜力.
科学领域:
- 皮肤病学和微生物学
- 皮肤屏障研究研究
- 后生物疗法 后生物疗法
背景情况:
- 后生物质因其调节免疫反应和促进组织再生的作用而越来越受认可.
- 了解它们在护肤中的特定机制对于开发有效治疗方法至关重要.
- 关键的细菌菌株和尼古丁胺 (NAM) 等化合物显示出对皮肤健康的前景.
研究的目的:
- 研究来自Bifidobacterium breve,Limosilactobacillus reuteri和Ligilactobacillus salivarius的全细胞后生物在人类皮肤上的作用,结合NAM.
- 阐明它们对角质细胞功能和皮肤屏障完整性影响的机制.
- 评估它们对普通清洁剂引起的皮肤损伤的保护作用.
主要方法:
- 使用了ex vivo人类皮肤模型.
- 使用电阻谱法 (EIS) 来测量皮肤屏障的完整性.
- 集成的多组学 (基因组学,转录组学等) 和机器学习分析.
- 对角质细胞生长,分化和炎症通路的评估影响.
主要成果:
- B. breve,L. reuteri和L. salivarius后生物,具有NAM,增强了角质细胞的生长,分化和皮肤屏障完整性.
- B. breve促进了分化和抑制了炎症;L. reuteri和L. salivarius减少了炎症.
- 尽管降低了分化的调节,但NAM显示出抗炎作用.
- 机器学习确定了EIS数据与特定基因之间的联系,揭示了菌株特定的机制.
- 所有测试的后生物和NAM都减轻了清洁剂引起的皮肤损伤.
结论:
- 后生菌和NAM的组合有效地加强了皮肤屏障,并减少了炎症.
- 多omics和机器学习与皮肤屏障测量相结合,提供了一种强大的方法来剖析治疗机制.
- 这些发现支持特定后生物和NAM在先进的皮肤护理应用中的治疗潜力.
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