自然产品作为败血症引起的心肌功能障碍的多目标疗法 (综述)
Fei Tang1, Dong Liu2, Shi-Chao Zhu1
1Department of Pharmacy, Chongqing General Hospital, Chongqing University, Chongqing 400014, P.R. China.
International journal of molecular medicine
|January 23, 2026
概括
天然产品提供了针对败血症诱导的心肌功能障碍 (SIMD) 的多重目标策略,这是死亡的主要原因. 本综述探讨了它们的心脏保护机制,指导未来的SIMD疗法和补充剂.
科学领域:
- 心血管研究研究心血管研究
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 败血症是全球主要的死亡原因,败血症引起的心肌功能障碍 (SIMD) 显著增加了患者的死亡率.
- SIMD复杂的病理生理学包括炎症,氧化应激,线粒体功能障碍和亡,没有确立有效的治疗方法.
- 天然产品在治疗心血管疾病的传统医学中具有悠久的历史,提供潜在的心脏保护性益处.
研究的目的:
- 审查SIMD的临床表现和病理生理学.
- 总结天然产品对SIMD的心脏保护机制.
- 探索结构-活性关系,并确定SIMD处理中的天然产品的分子标.
主要方法:
- 对SIMD的临床表现和病理生理学的文献综述.
- 在SIMD中分析天然产品对炎症,氧化应激,亡和线粒体功能的影响.
- 探索自然产品与SIMD相关蛋白质的结构-活性关系和结合亲缘关系.
主要成果:
- 天然产品可以调节炎症路径,减少氧化应激,抑制亡,并改善SIMD中的线粒体功能.
- 突出了各种自然产品对SIMD相关蛋白质的关键分子标和结合亲和力.
- 结构-活性关系分析为设计有效的SIMD向自然化合物提供了洞察力.
结论:
- 自然产品为打击SIMD提供了多目标战略.
- 本综述为发现以SIMD为重点的食补充剂和化合物提供了指导.
- 这些发现为未来的翻译研究奠定了基础,用于开发SIMD的新疗法.
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