曼吉费林在人类疾病中的作用:多方面的机制和应用 (综述)
Yaling Dai1, Qiuling Huang2, Mengquan Tan3
1Fujian Key Laboratory of Aptamers Technology, 900th Hospital of Joint Logistics Support Force, Fuzhou, Fujian 350025, P.R. China.
International journal of molecular medicine
|January 23, 2026
概括
曼吉费林 (MGF) 通过调节关键信号通路,显示出对代谢,炎症和癌症疾病的前景. 临床使用受到生物利用度的限制,但交付策略可能会增强其治疗潜力.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 翻译医学是一种翻译医学.
背景情况:
- 曼吉费林 (MGF) 是一种具有多样化的生物活性的天然C-葡萄糖色.
- MGF的目标是AMP激活蛋白激酶,NF-κB,PI3K/AKT和MAPK信号通路.
- 这些途径在代谢,炎症和癌症疾病过程中至关重要.
研究的目的:
- 审查曼吉费林 (MGF) 的药理动力学和机制.
- 总结MGF在代谢,炎症和癌症疾病环境中的影响.
- 确定MGF临床转换的关键缺口和优先事项.
主要方法:
- 对MGF对细胞信号通路的影响的文献综述.
- 分析MGF对葡萄糖/脂质代谢,氧化应激,亡和炎症的影响.
- 评估MGF在代谢障碍和癌症模型中的临床前疗效.
- 评估MGF的抗炎作用,包括细胞因子释放和炎症酶调节.
主要成果:
- MGF改善了胰岛素敏感性,线粒体功能,并减少了糖尿病并发症.
- MGF抑制癌细胞的增殖,入侵,血管生成,并影响抗瘤免疫力.
- 通过减少细胞因子的释放和调节NLRP3炎症酶,MGF表现出抗炎作用.
- 低水溶性,口服生物利用性差,以及快速的新陈代谢限制了MGF的临床转化.
结论:
- 纳米载体输送,结构优化和组合疗法显示出改善MGF暴露和疗效的潜力.
- 在动物身上存在有利的安全信号,但临床证据有限.
- 翻译的优先事项包括标准化临床试验,优化交付策略和严格的长期安全性/有效性评估.
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