作为上肢神经损伤的虚拟活检的第二波生成成像:一个尸体研究
Christoph A Schroen1,2, Philip Nasser1, Damien Laudier1
1Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
概括
二次波生成 (SHG) 显微镜可以可视化人类神经原结构. SHG成像成功识别了神经损伤,区分了健康的神经和那些有伸展引起的损伤的人.
科学领域:
- 生物医学工程 生物医学工程
- 显微镜的使用方法
- 神经科学是一个神经科学.
背景情况:
- 准确的神经损伤评估对于及时的临床决策至关重要.
- 第二波子 (SHG) 显微镜提供了一种可视化原蛋白的方法,原蛋白是神经组织的关键成分.
- 这项研究旨在评估SHG成像在人类神经中的能力.
研究的目的:
- 为了确定SHG成像是否可以在人体神经内区分原基结构.
- 评估SHG成像在机械损伤后检测人类神经结构损伤的能力.
主要方法:
- 人类上肢被分为无损伤和负载到故障 (LTF) 组.
- 神经 (中间,辐射,) 经历了机械拉伸损伤的截断.
- 使用SHG显微镜对神经进行成像,随后进行组织学分析.
主要成果:
- SHG成像清楚地识别和区分了未受伤的神经中的所有原基结构,匹配组织学.
- 在LTF神经中,SHG成像揭示了上腺骨破裂和暴露的带.
- 在通过SHG受伤的神经中,有碎片纤维的无组织的上神经原显而易见.
结论:
- 这项研究开创了SHG显微镜用于可视化人类神经组织的使用.
- SHG成像提供了对外围神经原蛋白的详细可视化.
- SHG有效地检测神经结构损伤,包括原失调和囊暴露.
相关概念视频
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
397
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
397
Upper Respiratory Drugs: First and Second-Generation Antihistamines
1.1K
Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
1.1K
Harmonic Mean
3.7K
The arithmetic mean is usually skewed towards the larger values in the data set. Therefore, to avoid this inherent bias towards smaller values, the harmonic mean is used.
Take the example of the speed of a car, which is the measure of the rate of distance traveled. If the vehicle traverses the same distance back-and-forth, its average speed equals the total distance traveled divided by the total time taken. However, if the car moves with varying speeds, then the arithmetic mean is more skewed...
Take the example of the speed of a car, which is the measure of the rate of distance traveled. If the vehicle traverses the same distance back-and-forth, its average speed equals the total distance traveled divided by the total time taken. However, if the car moves with varying speeds, then the arithmetic mean is more skewed...
3.7K
Energy in Simple Harmonic Motion
12.6K
To determine the energy of a simple harmonic oscillator, consider all the forms of energy it can have during its simple harmonic motion. According to Hooke's Law, the energy stored during the compression/stretching of a string in a simple harmonic oscillator is potential energy. As the simple harmonic oscillator has no dissipative forces, it also possesses kinetic energy. In the presence of conservative forces, both energies can interconvert during oscillation, but the total energy remains...
12.6K
Virtual Work
1.4K
The principle of virtual work states that if a body is in static and dynamic equilibrium, then the sum of all the virtual work done by all external forces and couple moments for any given virtual displacement must be zero.
In static equilibrium, a body can experience an imaginary or virtual movement, such as displacement or rotation. The virtual work done by a force is equal to the dot product of force and virtual displacement in the direction of the force. When it comes to virtually rotating a...
In static equilibrium, a body can experience an imaginary or virtual movement, such as displacement or rotation. The virtual work done by a force is equal to the dot product of force and virtual displacement in the direction of the force. When it comes to virtually rotating a...
1.4K
Simple Harmonic Motion
14.7K
Simple harmonic motion is the name given to oscillatory motion for a system where the net force can be described by Hooke's law. If the net force can be described by Hooke's law and there is no damping (by friction or other non-conservative forces), then a simple harmonic oscillator will oscillate with equal displacement on either side of the equilibrium position. To derive an equation for period and frequency, the equation of motion is used. The period of a simple harmonic oscillator is given...
14.7K


