年龄不会影响患有普拉德-威利综合征的儿童在生长激素治疗前后呼吸系统的特征
Michelle Ip1, Sze Lut Cheng1, Okkes R Patoglu1
1Department of Paediatrics, Monash University, Melbourne, Australia.
Acta paediatrica (Oslo, Norway : 1992)
|January 23, 2026
概括
用生长激素治疗的普拉德-威利综合征 (PWS) 儿童没有增加睡眠呼吸暂停的风险. 非常小的儿童 (<2岁) 和较大的儿童 (≥2岁) 在阻塞性睡眠呼吸暂停 (OSA) 和中央睡眠呼吸暂停 (CSA) 的结果相似.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 睡眠医学 睡眠医学
- 遗传学 遗传学 是一个
背景情况:
- 普拉德-威利综合征 (PWS) 与中央睡眠呼吸暂停 (CSA) 和阻塞性睡眠呼吸暂停 (OSA) 的风险增加有关.
- 增长激素 (GH) 治疗通常在2岁之前在患有PWS的幼儿中开始.
- 之前关于GH对PWS睡眠呼吸暂停的影响的研究主要集中在年龄较大的儿童身上.
研究的目的:
- 评估年龄对PWS儿童OSA和CSA患病率的影响.
- 分析与年龄相关的睡眠和呼吸系统特征.
- 确定生长激素治疗对不同年龄组的OSA和CSA的影响.
主要方法:
- 追溯性回顾PWS儿童的多眠学数据.
- 在2011年1月至2024年6月期间收集的生长激素治疗前后数据.
- 在2岁以下的儿童和2岁以上的儿童之间,睡眠呼吸暂停指标的比较.
主要成果:
- 在GH治疗前,2岁以上的儿童比2岁以下的儿童更严重的OSA (p<0.05);在CSA严重程度上没有年龄差异.
- 在GH治疗后,OSA发生在21%的2岁以下儿童和20%的2岁以上儿童中.
- CSA在21% (<2年) 和6% (≥2年) 的患者中消失,而新发的CSA发生在11% (<2年) 和13% (≥2年) 的患者中.
结论:
- 增长激素治疗似乎不会增加患有PWS的非常年轻儿童患上OSA或CSA的风险.
- 在PWS治疗生长激素后,年龄不会显著影响睡眠呼吸暂停的发展或解决.
- 这些发现支持在患有PWS的儿童早期开始生长激素治疗的安全性,因为睡眠呼吸暂停的风险很大.
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