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在TEDDY研究中,甲状腺自身免疫和随后的小岛和腹自身免疫的发展
Joanna L Clasen1, Berglind Jonsdottir2,3, Kendra Vehik1
1Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
儿童甲状腺自身免疫增加了岛屿自身免疫和腹腔疾病自身免疫的风险. 甲状腺特异性自身抗体,如TPOAb,会影响这种风险,强调早期检测的重要性.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 自免疫性疾病 自免疫性疾病
- 遗传学 是一个遗传学.
背景情况:
- 甲状腺自身免疫在患有1型糖尿病遗传倾向的儿童中很常见.
- 甲状腺自身免疫与其他自身免疫状况 (如小岛自身免疫 (IA) 和腹腔疾病自身免疫 (CDA) 等) 的同时发生需要进一步调查.
研究的目的:
- 调查甲状腺自身免疫与高风险儿童IA和CDA随后发展之间的关联.
- 确定甲状腺自身抗体的类型是否影响IA和CDA的风险.
主要方法:
- 在"青少年糖尿病的环境决定因素" (TEDDY) 研究中,对5482名儿童进行了纵向随访.
- 对甲状腺过氧化酶抗体 (TPOAb),甲状腺蛋白抗体 (TGAb),IA和CDA的监测.
- 统计分析以评估共发生和风险关联,包括危险比率 (HR).
主要成果:
- 39%的儿童至少产生了一种自身抗体.
- 在14岁时,甲状腺自身免疫与IA (p=0.02) 和CDA (p=0.01) 同时显著发生.
- 甲状腺过氧化酶抗体 (TPOAb) -first与IA (HR 1.92) 和CDA (HR 1.69) 的风险增加有关,而甲状腺球蛋白抗体 (TGAb) -first没有显示任何关联.
结论:
- 甲状腺自身免疫经常与儿童和青少年的IA和CDA有关.
- 特定的最初甲状腺自身抗体 (TPOAb与TGAb) 影响了随后发展IA和CDA的风险.
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