最近被诊断患有癌症的儿童的发育障碍
Jamie Shoag1,2,3, Long Vu4, Ritika Miryala2
1Cleveland Clinic, Cleveland, Ohio, USA.
Pediatric blood & cancer
|January 23, 2026
概括
被诊断为癌症的儿童在诊断后不久就会面临发展障碍 (DD) 的两倍风险. 早期查和干预对于这些儿科癌症患者至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 在成人癌症幸存者中已知存在神经认知缺陷.
- 癌症诊断后不久在儿童中出现的发育障碍 (DD) 不太了解.
研究的目的:
- 调查癌症诊断后儿童发育障碍的患病率和风险.
- 为了比较儿科癌症患者与无癌症儿童的DD率.
主要方法:
- 利用了俄俄州癌症登记和医疗补助数据的2016-2019年链接.
- 在324名患有癌症的儿童中,与606,913名无癌症的对照人群相比,DD的患病率.
- 分析了DD风险的癌症前后诊断.
主要成果:
- 在诊断前的DD患病率在各组之间是相似的 (16%对16.9%).
- 在诊断后,患有癌症的儿童患DD的风险增加了一倍以上 (ARR2.09).
- 在多个发育领域观察到DD风险增加.
结论:
- 在儿童癌症诊断后,发育障碍迅速出现.
- 治疗和二次毒性可能导致DD风险增加.
- 强调儿童癌症患者早期查和康复干预的必要性.
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