生存的代价:神经母细胞瘤抗GD2免疫疗法的全球不平等
Ruzanna Papyan1,2,3, Julieta Hoveyan1,3, Martin Guscott4
1Yeolyan Hematology and Oncology Center, Yerevan, Armenia.
Pediatric blood & cancer
|January 23, 2026
概括
全球对神经母细胞瘤抗GD2抗体治疗的准入是不平等的,因为成本很高. 需要采取战略措施,改善低收入和中等收入国家的可用性和负担能力.
科学领域:
- 在瘤学瘤学.
- 药物经济学 药物经济学
- 全球健康 全球健康
背景情况:
- 高风险神经母细胞瘤的存活率通过抗GD2抗体治疗得到改善,但高成本造成了全球接入问题.
- 包括化疗,手术,辐射和抗GD2抗体在内的优化治疗方法提高了生存率.
- 这项研究解决了在全球范围内获得这些重要疗法的差异.
研究的目的:
- 评估针对神经母细胞瘤的抗GD2抗体治疗的全球可用性和财务覆盖.
- 识别障碍阻碍在各种医疗机构获得这些救命治疗的障碍.
- 评估不同收入国家的抗GD2疗法的经济负担.
主要方法:
- 一项在线调查收集了有关治疗可用性,财务覆盖和获取障碍的数据.
- 费舍尔的精确测试比较了高收入国家 (HIC) 和低收入和中等收入国家 (LMIC) 之间的治疗机会.
- 追溯性成本分析估计了一名儿科患者对抗GD2疗法的财务负担.
主要成果:
- 在93%的HIC中心提供抗GD2治疗,而在LMIC中心只有21%.
- 低,中等收入国家 (LMIC) 的中心面临着严重的访问限制,其中65%的人报告没有访问.
- 高成本 ($142,695-$610,800) 带来了巨大的财务负担,高产阶级企业依赖保险,低产阶级企业依赖自付款.
结论:
- 全球获得抗GD2治疗的机会显著不平等,HIC和LMIC之间存在重大差异.
- 谈判降低药物成本和列入必需药物清单对于公平获取至关重要.
- 基于研究的访问计划和国际合作对于克服财务和后勤障碍至关重要.
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