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Updated: Jan 24, 2026

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对UPAR与针对癌症治疗而开发的抗体结合的结构基础. 对灵活性,连接体识别和分子成像的机械洞察力

Rex F Anane1, Anni Kumari2,3, Hari Venugopal4

  • 1Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.

Protein science : a publication of the Protein Society
|January 23, 2026
PubMed
概括

一种新的抗uPAR抗体 (FL1) 重组了尿酶类型的血原激活体受体 (uPAR),增强了癌症治疗和PET成像. 这种结构洞察力改善了FL1-ADC的疗效和AE105成像用于癌症治疗监测.

关键词:
在 Ly6/uPAR 域中.抗体 - 药物结合物结合物具有竞争力的排斥取代.化-EMEM可以使用.塑原激活激活的方法表面的等离子体共振.在 uPAPA 中,

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