隐藏的储备高度适应的多宿主等离子体,在健康的人群中传播抗生素基因
Na Han1, Xianhui Peng1, Tingting Zhang1
1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
The ISME journal
|January 23, 2026
概括
对人类肠道等离子体的研究揭示了一种隐形等离子体,pGut1,在健康个体中普遍存在. 这种适应性强的等离子体无声无息地传播抗生素耐药性基因,可能为病原体提供装备,并推动抗菌素耐药性.
科学领域:
- 微生物组研究的研究.
- 基因组学就是基因组学.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 等离子体对于抗生素耐药性基因 (ARG) 的传播至关重要.
- 人体健康肠道微生物群中的等离子体的多样性和动态性尚不清楚.
研究的目的:
- 构建一个完整的健康人类肠道等离子体的图谱.
- 识别流行性质粒并描述它们在ARG传播中的作用.
主要方法:
- 来自498个人的便元基因组的分析.
- 等离子体重建和集群分析.
- 单细胞和纳米孔测序用于验证.
- 对230万个细菌基因组进行查.
主要成果:
- 在多样化的等离子体群中确定了17个流行性等离子体群 (>30%的流行率).
- 发现了pGut1,这是一个全球普遍存在的等离子体 (> 50%),具有稳定的骨干和可变的"插即用"模块.
- 在pGut1中记录了40个不同的货物插件,包括cfr{C},erm{B}和aphA等ARG.
- 在93个细菌菌株中发现了pGut1,跨越49个属,包括诸如Clostridioides difficile和Salmonella enterica之类的病原体.
结论:
- 健康的肠道含有像pGut1这样适应性质粒的储存库,它们无声地传播ARG.
- pGut1获得多种ARG的能力,以及它在各种宿主中的存在,表明它有可能跨物种传播给病原体.
- 这些发现突出了为推动多抗药性病原体的重大威胁.
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