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Updated: Jan 24, 2026

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
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Published on: October 5, 2020

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通过特定部位的白蛋白结合,向瘤提供EGFR抑制剂原药

Anja Federa1,2, Rastislav Pitek3, Orsolya Dömötör4

  • 1Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Str. 42, A-1090 Vienna, Austria.

Journal of medicinal chemistry
|January 23, 2026
PubMed
概括

这项研究开发了一种与专蛋白结合的前药物,用于osimertinib,一种表皮生长因子受体 (EGFR) 抑制剂,增强肺癌治疗. 这种新型药物输送系统在临床前模型中显示出更好的抗癌活性.

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