综合方法使黑色素瘤对放射治疗敏感
Abdullah A Aseeri1, Zahraa AlKhafaje2, Uday Abdul-Reda Hussein3
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. imahmood@kku.edu.sa.
概括
黑色素瘤治疗面临复杂的瘤微环境和抵抗机制带来的挑战. 针对DNA修复,免疫检查点和缺氧,有望提高黑色素瘤患者的放射治疗效率.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 辐射疗法 辐射疗法
背景情况:
- 黑色素瘤由于其复杂的瘤微环境 (TME) 和获得的抗性机制, presents显著的治疗挑战.
- 放射治疗,一种主要的黑色素瘤治疗,通过反应性氧物种 (ROS) 诱导DNA损伤,但癌细胞会产生DNA损伤反应 (DDR) 来抵御其影响.
- 瘤细胞与树皮细胞,免疫细胞和细胞外基质 (ECM) 相互作用,影响瘤的进展,转移和对放射治疗等疗法的耐药性.
研究的目的:
- 综合当前关于黑色素瘤瘤相互作用及其对放射治疗反应的影响的知识.
- 为改善黑色素瘤放射治疗结果提供有希望的分子点提供全面的概述.
主要方法:
- 文献综述综合了有关黑色素瘤TME,耐药机制和放射治疗的当前研究.
- 确定关键的细胞参与者和参与调节瘤对辐射反应的信号通路.
- 对新出现的分子标和治疗策略的分析.
主要成果:
- 黑色素瘤的TME组成部分,包括树皮细胞,免疫细胞 (巨细胞,T细胞) 和ECM,显著影响治疗耐药性.
- 瘤血管性和缺氧有助于放射电阻.
- 免疫检查点,生长因子和缺氧是辐射反应的关键调节器.
结论:
- 针对DNA修复抑制剂,免疫检查点抑制剂 (ICI),氨酸激酶抑制剂 (TKI) 和缺氧调节剂的新兴策略显示,有可能使黑色素瘤对放射治疗敏感.
- 了解和准黑色素瘤瘤相互作用对于改善放射治疗疗效和患者治疗结果至关重要.
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