评估活跃免疫免疫的避孕潜力,以防止淋巴激素释放激素的发生
Henryk F Urbanski1,2, Mark K Slifka1, Maria Luisa Appleman1
1Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.
概括
向性腺激素释放激素-II (GnRH-II) 并没有阻止 rhesus 的排卵. 这项研究质疑GnRH疫苗对避孕的有效性,但表明药理方法可能仍然是可行的.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 神经内分泌学神经内分泌学
- 免疫学 免疫学 免疫学
背景情况:
- 两种形式的GnRH,GnRH-I和GnRH-II,调节人类和 rhesus的月经周期.
- GnRH-I调解负面雌激素反,而GnRH-II则调解积极反,刺激LH激增.
- 选择性抑制GnRH-II可能会阻止排卵,并作为一种避孕策略.
研究的目的:
- 调查针对GnRH-II (和/或GnRH-I) 的活性免疫在预防雌性 rhesus macaques 排卵中的有效性.
- 评估GnRH-II作为新型避孕药开发目标的潜力.
主要方法:
- 雌性 rhesus 被积极免疫对抗 GnRH-II 和/或 GnRH-I.
- 在约2.5年内,每6周进行一次多次强制免疫接种.
- 血清雌激醇 (E2) 和孕激素 (P4) 度被监测以评估排卵.
主要成果:
- 尽管免疫接种和抗体度升高,但所有动物继续排卵,定期的P4峰值和月经表明了这一点.
- 在任何接受治疗的动物中都没有观察到排卵的停止.
结论:
- 对GnRH-II的活性免疫在阻断 rhesus macaques 排卵方面没有效果.
- 这些发现挑战了GnRH疫苗用于人类选择性排卵阻断的使用.
- 针对GnRH-II功能的药理干预仍然是避孕药开发的潜在途径.
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