快速PSA变化作为对PSMA-放射性干治疗反应的预后标志物
Wolfram A Bosbach1, Radi Saiyed Alsheikh1, Nasir Gözlügöl1
1Department of Nuclear Medicine, Inselspital, Bern, University Hospital of Bern, Bern, Switzerland.
European journal of nuclear medicine and molecular imaging
|January 23, 2026
概括
在前列腺特异性膜抗原放射性联体疗法 (PSMA-RLT) 后前列腺特异性抗原 (PSA) 的早期变化可以预测治疗的成功. 在PSMA-RLT后稳定或降低的PSA水平表明前列腺癌患者的反应更好,存活时间更长.
科学领域:
- 在瘤学瘤学.
- 核医学就是核医学.
- 放射性药物疗法是一种放射性药物疗法.
背景情况:
- 用[177Lu]Lu-PSMA-617进行前列腺特异性膜抗原放射性联体疗法 (PSMA-RLT) 是对转移性割抵抗性前列腺癌 (mCRPC) 的治疗方法.
- 在PSMA-RLT的早期预测治疗反应和存活率对于患者管理至关重要.
研究的目的:
- 调查前列腺特异性抗原 (PSA) 水平在第一个PSMA-RLT周期后两天内早期变化是否可以预测治疗反应和整体存活率.
- 在mCRPC患者中建立早期PSA动态和长期结果之间的相关性.
主要方法:
- 对76名用[177Lu]Lu-PSMA-617治疗的mCRPC患者进行了回顾性分析.
- 评估了治疗前PSA值和周期1后两天的相对PSA变化 (dPSA).
- 使用前列腺癌工作组 (PCWG3) 标准评估dPSA和生化反应 (BCR) 之间的相关性.
主要成果:
- 42%的患者显示PSA降低,59%的患者实现了部分反应 (PR).
- 在稳定PSA (46%) 的患者中,17人 (46%) 实现了PR.
- 与PSA增加 (225天) 患者相比,PSA降低或PSA稳定的患者的寿命更长 (分别为399天和405天).
结论:
- 在第一个[177Lu]Lu-PSMA-617循环后两天,PSA水平降低或稳定与有利的生化反应有关.
- 在PSMA-RLT后的早期PSA动态可以作为mCRPC患者治疗疗效和整体存活时间的预测生物标志物.
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