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自闭症中的肠道微生物群和线粒体功能障碍:临床相关性和未来方向
Sonalika Bhalla1, Rajnish Srivastava2
1Chitkara University School of Pharmacy, Chitkara University, Baddi, 174103, Himachal Pradesh, India.
Molecular neurobiology
|January 23, 2026
概括
自闭症谱系障碍 (ASD) 涉及肠道失调和线粒体功能障碍,影响肠-大脑轴. 调节微生物组和线粒体为ASD提供了潜在的治疗途径.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 遗传学 是一个
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,其特点是社会,行为和沟通障碍.
- 肠-大脑轴,包括肠道微生物群和线粒体功能,越来越被认为是ASD病理生理学的重要因素.
- 现有研究强调了ASD患者的肠道失调和线粒体功能障碍之间的相互作用.
研究的目的:
- 在ASD中全面审查肠道微生物群,微生物代谢物和线粒体功能障碍之间的关联.
- 探索肠-线粒体交叉和其在ASD病原发生中的作用.
- 确定关键的微生物代谢物和参与ASD的信号通路.
主要方法:
- 对过去十年的临床,实验和流行病学数据进行系统审查.
- 在ASD的背景下,分析研究肠-大脑轴的研究.
- 检查对微生物代谢物及其对线粒体功能的影响的研究.
主要成果:
- 自闭症患者表现出改变的肠道微生物群多样性,有益的微生物减少,致病性种群增加.
- 肠道微生物群的变化影响神经活性代谢物生物合成,影响免疫调节和神经传递.
- 微生物代谢物通过迷走神经,肠道激素和免疫信号调节线粒体活动,抑制AMPK,mTOR和NF-κB等途径.
结论:
- 肠道微生物群的改变和线粒体功能障碍在ASD中密切相关.
- 准微生物组和线粒体为ASD提供了一个有希望的治疗策略.
- 未来的研究应该专注于多学科和纵向研究,以阐明ASD的肠-大脑轴,以进行个性化治疗.
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